Question
A successful 2022 clinical trial that enrolled just five patients with this disease sparked efforts to treat it using CAR-T (“car T”) cells. For 10 points each:
[10m] Name this autoimmune disease that presents with a butterfly-shaped facial rash. However, its name is derived from a different animal.
ANSWER: lupus [or systemic lupus erythematosus; or SLE; accept lupus nephritis]
[10h] To treat autoimmune diseases, CARs are grafted onto these CD4 and CD25-positive T cells. These immuno·suppressive T cells prevent hyper·activation of helper T cells.
ANSWER: Tregs (“T regs”) [or regulatory T cells]
[10e] Before CAR-Tregs, lupus therapies dosed the mesenchymal (“mezz-en-KIE-mull”) type of these other cells. These pluripotent cells can be extracted from embryos and will differentiate into most other cell types.
ANSWER: stem cells [or embryonic stem cells or ESCs; or mesenchymal stem cells or MSCs]
<Adam Silverman, Science - Biology> ~23322~ <Editor: Adam Silverman>
Data
Summary
| Tournament | Edition | Exact Match? | Heard | PPB | Easy % | Medium % | Hard % |
|---|---|---|---|---|---|---|---|
| 2024 PACE NSC | 06/08/2024 | Y | 36 | 15.83 | 100% | 53% | 6% |