Question
In 2019, the FDA warned Kimera Therapeutics that it did, in fact, require approval to use this process to harvest drugs from cell cultures. For 10 points each:
[10m] Name this process by which cells secrete cargo using vesicles.
ANSWER: exocytosis [accept exosome formation; reject “endocytosis”]
[10e] Exosomes harvested from exocytosis could be good for drug delivery because they’re small enough to bypass the barrier that separates this organ in the CNS from central blood circulation.
ANSWER: brain [or blood-brain barrier; prompt on BBB]
[10h] Exosomes loaded with this enzyme have been sent across the blood-brain barrier as a preclinical treatment for Parkinson’s disease. This heme-containing enzyme is downstream of superoxide dismutase in cellular ROS detoxification pathways.
ANSWER: catalase
<Adam Silverman, Science - Biology> ~23381~ <Editor: Adam Silverman>
Data
| Team | Opponent | Part 1 | Part 2 | Part 3 | Total |
|---|---|---|---|---|---|
| Fairfield County AT | Lindbergh | 0 | 0 | 0 | 0 |
| Richard Montgomery A | Kinkaid | 10 | 10 | 10 | 30 |
Summary
| Tournament | Edition | Exact Match? | Heard | PPB | Easy % | Medium % | Hard % |
|---|---|---|---|---|---|---|---|
| 2024 PACE NSC | 06/08/2024 | Y | 2 | 15.00 | 50% | 50% | 50% |